AC Ca2+in AC Ca2+mob AC FOR AC Gs Akt ILK Akt PDK1 Akt PI3K Akt Rap1 AlphaA2-GPCR NE AP1 Fos Jun ATF1 CaMKII ATF1 MSK1 ATF1 PKA ATF1CREB CREB ATF1 ATF2 JNK ATF2 p38 BadEnd Akt BadEnd RSK Bcl2/BclXL BadEnd Bcl2/BclXL IL3 B-Raf Rap1 B-Raf Rit Ca2+in ACh Ca2+in cAMP/Ca2+in Ca2+in CNGC Ca2+in KCl Ca2+in leptin Ca2+in PACAP Ca2+in TrpC Ca2+mob PACAP Ca2+mob PLC CaM Ca2+in CaM Ca2+mob CaMKII CaM CaMKIV CaM cAMP AC cAMP cAMP/Ca2+in cAMP leptin cAMP-GEFII cAMP cdk5 p35 CnA CaM CNGC cAMP CRE ATF1 CRE ATF1CREB CRE CREB CREB Akt CREB CaMKIV CREB MAPKAPK2/3 CREB MSK1 CREB p38depkinase CREB PKA CREB PKA CREB PKC-theta CREB Rsk2 DAG PLC DAG PLD Egr1 ERK Elk ERK Elk JNK Elk p38 EndCaspase Akt ENKCnARE/CaRE NFAT ENKCRE2 AP1 ENKCRE2 CREB ERK MEK ERK NGF ERK Rap1 ERK Ras FkhEnd Akt Fos CREB Fos ERK Fos SRF Gq PACAP-R Gs PACAP-R IkB Akt IkB CnA IkB PKC IKK NGF ILK NGF IP3 PLC JNK MKK4/7 JNK Rac Jun CREB Jun JNK MAPKAPK2/3 p38 MEK Raf MEKK1 caspase MEKK1 MST1 MEKK1 PAK2 MEKK2/3 NIK MEKK2/3 PAK MKK3/6 ASK1 MKK4/7 ASK1 MKK4/7 MEKK1 MKK4/7 MEKK2/3 MSK1 ERK1/2 Mst1 Nore1 Mst1 RaSSF1 Munc13 DAG Munc13 PMA neurites NFkB neurites Akt neurites cdk5 neurites ERK1/2 neurites NO neurites p21WAF1 neurites p35 neurites Rsk1 NFAT CnA NFkB CaMKII NFkB IkB NFkB IKK NFkB p65p50 NFkB PAK1 NFkB Ras NO NOS Nore1 Ras NOS NGF p21WAF1 p21WAF1promoter p21WAF1promoter NO p35 Egr1 p38 JNKK p38 MKK6 p38 Rac p38depkinase p38 p53 NO p65p50 IKB PACAP-R PACAP PAK1 LPS PAK1 Rac1 PAK1 Raf1 PAK1 Ras PAKs Cdc42 PAKs Rac1 PDK1 PIP3 PEnkgeneholo ENKCRE2 PI3K Ras PI3K trkA PIP3 PI3K PKA cAMP PKC PI3K PKC PMA PKC-alpha DAG Ca2+mob PKC-alpha PMA PKC-theta DAG Ca2+mob PLC Gq PLD Src Rac Ras Raf PKC Raf PKC-alpha Raf Rap1 Raf Ras Rap1 cAMP Rap1 cAMP Rap1 cAMP-GEFII Rap1 Src Rap1End Rap1GAP Rap1GAP cAMP-GEF Rap1GAP Gz Ras Gbeta/gamma Ras PKC-epsilon Ras RasGRF Ras Shc/Grb2/Sos Ras trkA RasGRF Ca2+in RasGRF Ca2+mob RassF1 Ras RhoA PACAP-R Rsk1 ERK Rsk2 ERK Shc/Grb2/Sos trkA Src Gbeta/gamma Src PKA SRF CaMKIV survival Bcl2/BclX2 survival Fkh survival NFkB Tiam1 PI3K TRE AP1 trkA NGF VIPgeneCaRE NFAT VIPgeneCRE CREB VIPgeneCRE X VIPgeneholo VIPgeneCaRE