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pathFinder
pathFinder is a program which finds signal transduction pathways between
first, second, or nth messengers and targets within the cell. The usefulness
of pathFinder consists in its ability to identify all possible signal transduction
pathways connecting any starting component and target for a given set of
possible two-component pathways in the pathFinder database. At present,
there are 60 such two-step pathways in the pathFinder db. Addition of two-step
pathways is ongoing. pathFinder can also identify all pathways connecting
a starting component and a target when one or more intermediate pathway
components are removed (excluded). This allows investigation of minimal
activation sets and predicts effects of inhibitors of specific pathways
on target activation from a given nth intracellular messenger. pathFinder
is not quantitative: partial inhibitions and partial activations are not
within the purview of pathFinder. Combinatorial activations, however, can
be analyzed using pathFinder, although these are limited in the present
version. Please send your comments or requests for on-line tutorials on pathFinder to
eidenl@mail.nih.gov
pathFinder was conceived and constructed as a collaboration between Molecular
Science Institute's Larry Lok and Lee Eiden of the NIMH-IRP, and has been
adapted for Web use by Margaret Dayhoff-Brannigan, NIMH-IRP summer intern.
Run pathFinder
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